The aim of this study was to explore factors that influence stroke survivors' ability to persevere with home-based upper limb practice. A qualitative descriptive study embedded within a theoretical framework was conducted. Data were collected through semi-structured focus group, dyadic, and individual interviews. The Theoretical Domains Framework and Capability, Opportunity, Motivation - Behaviour (COM-B) model guided data collection and directed content analysis. Participants were 31 adult stroke survivors with upper limb impairment, with 13 significant other/s, who were living at home in Queensland, Australia. Three central tenants aligned with the COM-B and six themes were identified. Stroke survivors' capability to persevere was influenced by being physically able to practice and being able to understand, monitor and modify practice, their opportunity to persevere was influenced by accessing therapy and equipment required for practice and fitting practice into everyday life, and their motivation to persevere was influenced by having goals and experiencing meaningful outcomes and having support and being accountable. Persevering with practice is multifaceted for stroke survivors. All facets need to be addressed in the design of strategies to enhance stroke survivors' ability to persevere and in turn, enhance their potential for continued upper limb recovery. IMPLICATIONS FOR REHABILITATION Many stroke survivors do not persevere with long-term home-based upper limb practice despite the belief that high dose practice will promote continued recovery. Therapists need to support stroke survivors to setup individualised goal-based home programs that they can complete independently, or with support, within their everyday life. Stroke survivors need coaching to monitor and modify their practice and map their progress, so that they can recognise and experience meaningful recovery. To optimise upper limb recovery after stroke, strategies to enhance stroke survivors' capability , opportunity , and motivation to persevere across the continuum of recovery, need to be co-designed by stroke survivors, therapists and researchers.