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Gwinn, Dana M.; Lee, Alex G.; Briones-Martin-del-Campo, Marcela; Conn, Crystal S.; Simpson, David R.; Scott, Anna I.; Le, Anthony; Cowan, Tina M.; Ruggero, Davide; Sweet-Cordero, E. Alejandro
Cancer cell, 01/2018, Letnik: 33, Številka: 1Journal Article
KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of this pathway during nutrient stress; loss of KEAP1 in KRAS mutant cells leads to apoptosis. Through ATF4 regulation, KRAS alters amino acid uptake and asparagine biosynthesis. The ATF4 target asparagine synthetase (ASNS) contributes to apoptotic suppression, protein biosynthesis, and mTORC1 activation. Inhibition of AKT suppressed ASNS expression and, combined with depletion of extracellular asparagine, decreased tumor growth. Therefore, KRAS is important for the cellular response to nutrient stress, and ASNS represents a promising therapeutic target in KRAS mutant NSCLC. •KRAS regulates the transcriptional response to nutrient stress via ATF4•The PI3K-AKT pathway modulates NRF2 activity to regulate ATF4•ASNS is a key target of the KRAS-ATF4 axis in NSCLC•AKT inhibition with L-asparaginase treatment is an effect combination therapy Gwinn et al. show that oncogenic KRAS regulates amino acid homeostasis and cellular response to nutrient stress via ATF4. They identify ASNS as a key target of the KRAS-ATF4 axis in KRAS-driven non-small-cell lung cancer, revealing a therapeutic vulnerability in asparagine biosynthesis.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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