E-viri
Recenzirano
Odprti dostop
-
Todaro, Matilde; Gaggianesi, Miriam; Catalano, Veronica; Benfante, Antonina; Iovino, Flora; Biffoni, Mauro; Apuzzo, Tiziana; Sperduti, Isabella; Volpe, Silvia; Cocorullo, Gianfranco; Gulotta, Gaspare; Dieli, Francesco; De Maria, Ruggero; Stassi, Giorgio
Cell stem cell, 03/2014, Letnik: 14, Številka: 3Journal Article
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors. CD44v6 expression is low in primary tumors but demarcated clonogenic CR-CSC populations. Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis. CD44v6− progenitor cells do not give rise to metastatic lesions but, when treated with cytokines, acquire CD44v6 expression and metastatic capacity. Importantly, phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD44v6 CR-CSCs and reduced metastatic growth. In patient cohorts, low levels of CD44v6 predict increased probability of survival. Thus, the metastatic process in colorectal cancer is initiated by CSCs through the expression of CD44v6, which is both a functional biomarker and therapeutic target. Display omitted •CD44v6 is a CR-CSC marker required for the metastatic potential of CSCs•Tumor niche reprograms CD44v6− CRC progenitors in metastatic CD44v6+ stem cells•PI3K inhibition impairs the metastatic activity of CD44v6+ CR-CSCs•CD44v6 expression is an independent negative prognostic marker Todaro et al. show that colorectal cancer stem cells in response to niche signals upregulate an isoform of CD44 (CD44v6) that is required for their migration and capacity to generate metastatic tumors.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.