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Zhang, Xing; Khalidi, Omar; Kim, So Young; Wang, Ruitong; Schultz, Victor; Cress, Brady F.; Gross, Richard A.; Koffas, Mattheos A.G.; Linhardt, Robert J.
Bioorganic & medicinal chemistry letters, 07/2016, Letnik: 26, Številka: 13Journal Article
Display omitted A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.
