Improved understanding of the effects of meteorological conditions on the transmission of SARS-CoV-2, the causative agent for COVID-19 disease, is needed. Here, we estimate the relationship between air temperature, specific humidity, and ultraviolet radiation and SARS-CoV-2 transmission in 2669 U.S. counties with abundant reported cases from March 15 to December 31, 2020. Specifically, we quantify the associations of daily mean temperature, specific humidity, and ultraviolet radiation with daily estimates of the SARS-CoV-2 reproduction number (R ) and calculate the fraction of R attributable to these meteorological conditions. Lower air temperature (within the 20-40 °C range), lower specific humidity, and lower ultraviolet radiation were significantly associated with increased R . The fraction of R attributable to temperature, specific humidity, and ultraviolet radiation were 3.73% (95% empirical confidence interval eCI: 3.66-3.76%), 9.35% (95% eCI: 9.27-9.39%), and 4.44% (95% eCI: 4.38-4.47%), respectively. In total, 17.5% of R was attributable to meteorological factors. The fractions attributable to meteorological factors generally were higher in northern counties than in southern counties. Our findings indicate that cold and dry weather and low levels of ultraviolet radiation are moderately associated with increased SARS-CoV-2 transmissibility, with humidity playing the largest role.