E-viri
Recenzirano
Odprti dostop
-
Boutros, Paul C; Fraser, Michael; Harding, Nicholas J; de Borja, Richard; Trudel, Dominique; Lalonde, Emilie; Meng, Alice; Hennings-Yeomans, Pablo H; McPherson, Andrew; Sabelnykova, Veronica Y; Zia, Amin; Fox, Natalie S; Livingstone, Julie; Shiah, Yu-Jia; Wang, Jianxin; Beck, Timothy A; Have, Cherry L; Chong, Taryne; Sam, Michelle; Johns, Jeremy; Timms, Lee; Buchner, Nicholas; Wong, Ada; Watson, John D; Simmons, Trent T; P'ng, Christine; Zafarana, Gaetano; Nguyen, Francis; Luo, Xuemei; Chu, Kenneth C; Prokopec, Stephenie D; Sykes, Jenna; Dal Pra, Alan; Berlin, Alejandro; Brown, Andrew; Chan-Seng-Yue, Michelle A; Yousif, Fouad; Denroche, Robert E; Chong, Lauren C; Chen, Gregory M; Jung, Esther; Fung, Clement; Starmans, Maud H W; Chen, Hanbo; Govind, Shaylan K; Hawley, James; D'Costa, Alister; Pintilie, Melania; Waggott, Daryl; Hach, Faraz; Lambin, Philippe; Muthuswamy, Lakshmi B; Cooper, Colin; Eeles, Rosalind; Neal, David; Tetu, Bernard; Sahinalp, Cenk; Stein, Lincoln D; Fleshner, Neil; Shah, Sohrab P; Collins, Colin C; Hudson, Thomas J; McPherson, John D; van der Kwast, Theodorus; Bristow, Robert G
Nature genetics, 07/2015, Letnik: 47, Številka: 7Journal Article
Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We initially determined the copy number aberration (CNA) profiles of 74 patients with index tumors of Gleason score 7. Of these, 5 patients were subjected to whole-genome sequencing using DNA quantities achievable in diagnostic biopsies, with detailed spatial sampling of 23 distinct tumor regions to assess intraprostatic heterogeneity in focal genomics. Multifocal tumors are highly heterogeneous for single-nucleotide variants (SNVs), CNAs and genomic rearrangements. We identified and validated a new recurrent amplification of MYCL, which is associated with TP53 deletion and unique profiles of DNA damage and transcriptional dysregulation. Moreover, we demonstrate divergent tumor evolution in multifocal cancer and, in some cases, tumors of independent clonal origin. These data represent the first systematic relation of intraprostatic genomic heterogeneity to predicted clinical outcome and inform the development of novel biomarkers that reflect individual prognosis.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.