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Gaboriau-Routhiau, Valérie; Rakotobe, Sabine; Lécuyer, Emelyne; Mulder, Imke; Lan, Annaïg; Bridonneau, Chantal; Rochet, Violaine; Pisi, Annamaria; De Paepe, Marianne; Brandi, Giovanni; Eberl, Gérard; Snel, Johannes; Kelly, Denise; Cerf-Bensussan, Nadine
Immunity, 10/2009, Letnik: 31, Številka: 4Journal Article
Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine balance at steady-state and the role of individual bacterial species in setting the balance remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. This function appeared the prerogative of a restricted number of bacteria, the prototype of which is the segmented filamentous bacterium, a nonculturable Clostridia-related species, which could largely recapitulate the coordinated maturation of T cell responses induced by the whole mouse microbiota. This bacterium, already known as a potent inducer of mucosal IgA, likely plays a unique role in the postnatal maturation of gut immune functions. Changes in the infant flora may thus influence the development of host immune responses.
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in: SICRIS
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