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Prapa, Malvina; Chiavelli, Chiara; Golinelli, Giulia; Grisendi, Giulia; Bestagno, Marco; Di Tinco, Rosanna; Dall'Ora, Massimiliano; Neri, Giovanni; Candini, Olivia; Spano, Carlotta; Petrachi, Tiziana; Bertoni, Laura; Carnevale, Gianluca; Pugliese, Giuseppe; Depenni, Roberta; Feletti, Alberto; Iaccarino, Corrado; Pavesi, Giacomo; Dominici, Massimo
NPJ precision oncology, 10/2021, Letnik: 5, Številka: 1Journal Article
Glioblastoma is the most malignant primary brain tumor and is still in need of effective medical treatment. We isolated patient-derived glioblastoma cells showing high GD2 antigen expression representing a potential target for CAR T strategy. Data highlighted a robust GD2 CAR antitumor potential in 2D and 3D glioblastoma models associated with a significant and CAR T-restricted increase of selected cytokines. Interestingly, immunosuppressant TGF β1, expressed in all co-cultures, did not influence antitumor activity. The orthotopic NOD/SCID models using primary glioblastoma cells reproduced human histopathological features. Considering still-conflicting data on the delivery route for targeting brain tumors, we compared intracerebral versus intravenous CAR T injections. We report that the intracerebral route significantly increased the length of survival time in a dose-dependent manner, without any side effects. Collectively, the proposed anti-GD2 CAR can counteract human glioblastoma potentially opening a new therapeutic option for a still incurable cancer.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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