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Lennon, Anne Marie; Buchanan, Adam H; Kinde, Isaac; Warren, Andrew; Honushefsky, Ashley; Cohain, Ariella T; Ledbetter, David H; Sanfilippo, Fred; Sheridan, Kathleen; Rosica, Dillenia; Adonizio, Christian S; Hwang, Hee Jung; Lahouel, Kamel; Cohen, Joshua D; Douville, Christopher; Patel, Aalpen A; Hagmann, Leonardo N; Rolston, David D; Malani, Nirav; Zhou, Shibin; Bettegowda, Chetan; Diehl, David L; Urban, Bobbi; Still, Christopher D; Kann, Lisa; Woods, Julie I; Salvati, Zachary M; Vadakara, Joseph; Leeming, Rosemary; Bhattacharya, Prianka; Walter, Carroll; Parker, Alex; Lengauer, Christoph; Klein, Alison; Tomasetti, Cristian; Fishman, Elliot K; Hruban, Ralph H; Kinzler, Kenneth W; Vogelstein, Bert; Papadopoulos, Nickolas
Science (American Association for the Advancement of Science), 07/2020, Letnik: 369, Številka: 6499Journal Article
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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