E-viri
Recenzirano
Odprti dostop
-
Okumura, Shintaro; Konishi, Yusuke; Narukawa, Megumi; Sugiura, Yuki; Yoshimoto, Shin; Arai, Yuriko; Sato, Shintaro; Yoshida, Yasuo; Tsuji, Shunya; Uemura, Ken; Wakita, Masahiro; Matsudaira, Tatsuyuki; Matsumoto, Tomonori; Kawamoto, Shimpei; Takahashi, Akiko; Itatani, Yoshiro; Miki, Hiroaki; Takamatsu, Manabu; Obama, Kazutaka; Takeuchi, Kengo; Suematsu, Makoto; Ohtani, Naoko; Fukunaga, Yosuke; Ueno, Masashi; Sakai, Yoshiharu; Nagayama, Satoshi; Hara, Eiji
Nature communications, 09/2021, Letnik: 12, Številka: 1Journal Article
Abstract Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development. Here we show that 12 faecal bacterial taxa are enriched in CRC patients in two independent cohort studies. Among them, 2 Porphyromonas species are capable of inducing cellular senescence, an oncogenic stress response, through the secretion of the bacterial metabolite, butyrate. Notably, the invasion of these bacteria is observed in the CRC tissues, coinciding with the elevation of butyrate levels and signs of senescence-associated inflammatory phenotypes. Moreover, although the administration of these bacteria into Apc Δ14/+ mice accelerate the onset of colorectal tumours, this is not the case when bacterial butyrate-synthesis genes are disrupted. These results suggest a causal relationship between Porphyromonas species overgrowth and colorectal tumourigenesis which may be due to butyrate-induced senescence.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.