E-viri
Recenzirano
Odprti dostop
-
Tran, Thi Nhu Mai; May, Bruce Pearson; Ung, Trong Thuan; Nguyen, Mai Khoi; Nguyen, Thi Thuy Trang; Dinh, Van Long; Doan, Chinh Chung; Tran, The Vinh; Khong, Hiep; Nguyen, Thi Thanh Truc; Hua, Hoang Quoc Huy; Nguyen, Viet Anh; Ha, Tan Phat; Phan, Dang Luu; Nguyen, Truong An; Bui, Thi Ngoc; Tu, Tieu My; Nguyen, Thi Theo; Le, Thi Thuy Hang; Dong, Thi Lan; Huynh, Trong Hieu; Ho, Phien Huong; Le, Nguyen Thanh Thao; Truong, Cong Thao; Pham, Hoang Phi; Luong, Cong Y; Y, Nie Lim; Cao, Minh Ngoc; Nguyen, Duy Khanh; Le, Thi Thanh; Vuong, Duc Cuong; Nguyen, Le Khanh Hang; Do, Minh Si
Frontiers in immunology, 12/2021, Letnik: 12Journal Article
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health concern. The development of vaccines with high immunogenicity and safety is crucial for controlling the global COVID-19 pandemic and preventing further illness and fatalities. Here, we report the development of a SARS-CoV-2 vaccine candidate, Nanocovax, based on recombinant protein production of the extracellular (soluble) portion of the spike (S) protein of SARS-CoV-2. The results showed that Nanocovax induced high levels of S protein-specific IgG and neutralizing antibodies in three animal models: BALB/c mouse, Syrian hamster, and a non-human primate ( ). In addition, a viral challenge study using the hamster model showed that Nanocovax protected the upper respiratory tract from SARS-CoV-2 infection. Nanocovax did not induce any adverse effects in mice ( var. albino) and rats ( ). These preclinical results indicate that Nanocovax is safe and effective.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.