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Cérbulo-Vázquez, A; García-Espinosa, M; Briones-Garduño, J. C; Arriaga-Pizano, L; Ferat-Osorio, E; Zavala-Barrios, B; Cabrera-Rivera, G. L; Miranda-Cruz, P; García de la Rosa, M. T; Prieto-Chávez, J. L; Rivero-Arredondo, V; Madera-Sandoval, R. L; Cruz-Cruz, A; Salazar-Rios, E; Salazar-Rios, M. E; Serrano-Molina, D; De Lira-Barraza, R. C; Villanueva-Compean, A. H; Esquivel-Pineda, A; Ramirez-Montes de Oca, R; Caldiño-Soto, F; Ramírez-García, L. A; Flores-Padilla, G; Moreno-Álvarez, O; Guerrero-Avendaño, G. M. L; López-Macías, C
PloS one, 07/2022, Letnik: 17, Številka: 7Journal Article
Current medical guidelines consider pregnant women with COVID-19 to be a high-risk group. Since physiological gestation downregulates the immunological response to maintain “maternal-fetal tolerance”, SARS-CoV-2 infection may constitute a potentially threatening condition to both the mother and the fetus. To establish the immune profile in pregnant COVID-19+ patients, a cross-sectional study was conducted. Pregnant women with COVID-19 (P-COVID-19+; n = 15) were analyzed and compared with nonpregnant women with COVID-19 (NP-COVID-19+; n = 15) or those with physiological pregnancy (P-COVID-19-; n = 13). Serological cytokine and chemokine concentrations, leucocyte immunophenotypes, and mononuclear leucocyte responses to polyclonal stimuli were analyzed in all groups. Higher concentrations of serological TNF-α, IL-6, MIP1b and IL-4 were observed within the P-COVID-19+ group, while cytokines and chemokines secreted by peripheral leucocytes in response to LPS, IL-6 or PMA-ionomicin were similar among the groups. Immunophenotype analysis showed a lower percentage of HLA-DR+ monocytes in P-COVID-19+ than in P-COVID-19- and a higher percentage of CD39+ monocytes in P-COVID-19+ than in NP-COVID-19+. After whole blood polyclonal stimulation, similar percentages of T cells and TNF+ monocytes between groups were observed. Our results suggest that P-COVID-19+ elicits a strong inflammatory response similar to NP-COVID19+ but also displays an anti-inflammatory response that controls the ATP/adenosine balance and prevents hyperinflammatory damage in COVID-19.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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