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Pievani, Michela; Bocchetta, Martina; Boccardi, Marina; Cavedo, Enrica; Bonetti, Matteo; Thompson, Paul M; Frisoni, Giovanni B
Neurobiology of aging, 07/2013, Letnik: 34, Številka: 7Journal Article
Abstract We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E ( APOE ) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen ( p < 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes ( p < 0.05; Mann–Whitney test) and shape ( p < 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions ( p < 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD ϵ4 carriers and noncarriers in the left and right caudate ( p < 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.
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