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  • Inhibitors of apoptosis (IA...
    Pedersen, Jannie; LaCasse, Eric C; Seidelin, Jakob B; Coskun, Mehmet; Nielsen, Ole H

    Trends in molecular medicine, 11/2014, Letnik: 20, Številka: 11
    Journal Article

    Highlights • Several inhibitors of apoptosis (IAPs) mediate immune signaling through their ubiquitin ligase function. • Additional IAPs control immunity through the regulation of the inflammasome. • The IAPs contribute to immunity and immune disorders, such as inflammatory bowel disease (IBD). • X-chromosome-linked IAP (XIAP) deficiency is now recognized as a monogenic cause of severe Crohn's-like disease.