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Malmhäll, Carina; Weidner, Julie; Rådinger, Madeleine
Cellular & molecular immunology, 05/2020, Letnik: 17, Številka: 5Journal Article
MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression at the post-transcriptional level, thereby serving as important cellular regulators.1 However, miRNA expression in specific human cellular subtypes, especially at the single-cell level, remains largely unexplored. In this study, a novel method called the PrimeFlow™ RNA Assay2 was used to directly monitor miRNA expression in the cell. Notably, we demonstrate for the first time that human innate lymphoid cells (ILCs) express miR-155. We further demonstrate a clear distinction between the sexes, with a significant increase in the number of ILCs expressing miR-155 in female-derived cells compared with male-derived cells upon in vitro stimulation.
