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Virtue, Samuel; Vidal-Puig, Antonio
PLoS biology, 09/2008, Letnik: 6, Številka: 9Journal Article
The adipose tissue expandability hypothesis suggests that the insulin resistance found in lipodystrophic and obese individuals is caused by the same pathogenic mechanism of impaired adipose tissue expansion capacity, even if the underlying cause and degree of impairment in adipose tissue expansion may be very different.\n It also integrates explanations of how changes in lipid handling and adipocyte size may interact to lead to inflammation, dyslipidaemia, and ultimately to diabetes. ...the adipose tissue expansion hypothesis may allow for the design of better obesity treatment regimes, particularly with respect to personalised weight loss programs.
