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Wong, Jason Y.Y.; Hsiung, Chao A.; Shiraishi, Kouya; Matsuo, Keitaro; Wong, Maria Pik; Hong, Yun-Chul; Wang, Jiucun; Seow, Wei Jie; Song, Minsun; Hu, Wei; Wu, Chen; Seow, Adeline; Caporaso, Neil E.; Chung, Lap Ping; An, She-Juan; Wang, Ping; Yang, Yang; Zhang, Xu-Chao; Kim, Young-Chul; Bassig, Bryan A.; Ho, James Chung Man; Daigo, Yataro; Ashikawa, Kyota; Kamatani, Yoichiro; Honda, Takayuki; Hosgood, H. Dean; Sakamoto, Hiromi; Kunitoh, Hideo; Watanabe, Shun-ichi; Miyagi, Yohei; Matsumoto, Shingo; Song, Lei; Minamiya, Yoshihiro; Matsuda, Fumihiko; Oh, In-Jae; Song, Fengju; Su, Wu-Chou; Chen, Kuan-Yu; Chien, Li-Hsin; Chen, Chien-Jen; Lee, Kyoung-Mu; Blechter, Batel; Gao, Yu-Tang; Qian, Biyun; Lu, Daru; Liu, Jianjun; Jeon, Hyo-Sung; Hsiao, Chin-Fu; Guo, Huan; Hu, Zhibin; Chung, Charles C.; Yeager, Meredith; Pang, Herbert; Park, Kyong Hwa; Sung, Sook Whan; Kang, C.H.; Zhu, Meng; Guan, Peng; Wang, Chih-Liang; Ho, James; Hung, Jen-Yu; Yoon, Ho Il; Lin, Chien-Chung; Xu, Ping; Wang, Yuzhuo; He, Qincheng; Perng, Reury-Perng; Chen, Chih-Yi; Wu, Junjie; Li, Yao-Jen; Jin, Li; Jiang, Shih-Sheng; Liu, Jie; Yamaji, Taiki; Hicks, Belynda; Li, Shengchao A.; Dai, Juncheng; Ma, Hongxia; Song, Bao; Wang, Zhehai; Cheng, Sensen; Cui, Ping; Shimazu, Taichi; Yang, Kaiyun; Jiang, Gening; Fei, Ke; Wu, Guoping; Fang, Yao-Huei; Hsieh, Wan-Shan; Stevens, Victoria L.; Laird-Offringa, Ite A.; Rieswijk, Linda; Yang, Pan-Chyr; Shu, Xiao-Ou; Wu, Y.L.; Lin, Dongxin; Huang, Yun-Chao; Shen, Hongbing; Chanock, Stephen J.; Rothman, Nathaniel
Genomics (San Diego, Calif.), 03/2020, Letnik: 112, Številka: 2Journal Article
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
