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Kleynhans, Jackie; Tempia, Stefano; Wolter, Nicole; von Gottberg, Anne; Bhiman, Jinal N; Buys, Amelia; Moyes, Jocelyn; McMorrow, Meredith L; Kahn, Kathleen; Gomez- Olive, F. Xavier; Tollman, Stephen; Martinson, Neil A; Wafawanaka, Floidy; Lebina, Limakatso; Toit, Jacques du; Jassat, Waasila; Neti, Mzimasi; Brauer, Marieke; Cohen, Cheryl
Emerging infectious diseases, 12/2021, Letnik: 27, Številka: 12Journal Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection–case, infection–hospitalization, and infection–fatality ratios in 2 waves of infection. Post–second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35–59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35–59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection–fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
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in: SICRIS
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