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Zanardi, Alan; Barbariga, Marco; Conti, Antonio; Vegliani, Franco; Curnis, Flavio; Alessio, Massimo
Neurobiology of disease, October 2021, 2021-10-00, 20211001, 2021-10-01, Letnik: 158Journal Article
Choroid plexus epithelial cells (CPEpiCs) determine the composition of cerebrospinal fluid (CSF) and constitute the blood-CSF barrier (BCSFB), functions that are altered in neurodegenerative diseases. In Parkinson's disease (PD) the pathological environment oxidizes and deamidates the ceruloplasmin, a CSF-resident ferroxidase, which undergoes a gain of RGD-recognizing integrin binding property, that may result in signal transduction. We investigated the effects that oxidized/deamidated ceruloplasmin (Cp-ox/de) may exert on CPEpiCs functions. Through RGD-recognizing integrins binding, Cp-ox/de mediates CPEpiCs adhesion and intracellular signaling, resulting in cell proliferation inhibition and alteration of the secretome profile in terms of proteins related to cell-extracellular matrix interaction. Oxidative conditions, comparable to those found in the CSF of PD patients, induced CPEpiCs barrier leakage, allowing Cp-ox/de to cross it, transducing integrins-mediated signal that further worsens BCSFB integrity. This mechanism might contribute to PD pathological processes altering CSF composition and aggravating the already compromised BCSFB function. Display omitted •Oxidative stress in Parkinson's disease alters choroid plexus barrier permeability.•Ceruloplasmin is oxidized/deamidated in Parkinson's disease cerebrospinal fluid.•Modified ceruloplasmin binds to integrin and transduces an intracellular signal.•Ceruloplasmin integrin- binding alters choroid plexus cells secretome and proliferation.•Integrin-binding by modified ceruloplasmin worsens choroid plexus barrier integrity.
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