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Mathew, Bini; Hobrath, Judith V.; Lu, Wenyan; Li, Yonghe; Reynolds, Robert C.
Medicinal chemistry research, 2017/11, Letnik: 26, Številka: 11Journal Article
As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.
