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Seaton, Kelly E; Deal, Aaron; Han, Xue; Li, Shuying S; Clayton, Ashley; Heptinstall, Jack; Duerr, Ann; Allen, Mary A; Shen, Xiaoying; Sawant, Sheetal; Yates, Nicole L; Spearman, Paul; Churchyard, Gavin; Goepfert, Paul A; Maenza, Janine; Gray, Glenda; Pantaleo, Giuseppe; Polakowski, Laura; Robinson, Harriet L; Grant, Shannon; Randhawa, April K; Huang, Ying; Morgan, Cecilia; Grunenberg, Nicole; Karuna, Shelly; Gilbert, Peter B; McElrath, M Juliana; Huang, Yunda; Tomaras, Georgia D
npj vaccines, 04/2021, Letnik: 6, Številka: 1Journal Article
We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and the highest Env-specific IgG response rates. DNA/vector groups elicited mucosal Env-specific IgG response rates of up to 67% that varied across specimen types. Little to no mucosal IgA responses were observed. Overall, gp41- and gp140-specific antibodies dominated gp120 mucosal responses. In one trial, prior vaccination with a protein-containing immunogen maintained durability of cervical and rectal IgG for up to 17 years. Mucosal IgG responses were boosted after revaccination. These findings highlight a role for protein immunization in eliciting HIV-1-specific mucosal antibodies and the ability of HIV-1 vaccines to elicit durable HIV-1-specific mucosal IgG.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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