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Ivić, Vedrana; Zjalić, Milorad; Blažetić, Senka; Fenrich, Matija; Labak, Irena; Scitovski, Rudolf; Szűcs, Kálmán Ferenc; Ducza, Eszter; Tábi, Tamás; Bagamery, Fruzsina; Szökő, Éva; Vuković, Rosemary; Rončević, Alen; Mandić, Dario; Debeljak, Željko; Berecki, Monika; Balog, Marta; Seres-Bokor, Adrienn; Sztojkov-Ivanov, Anita; Hajagos-Tóth, Judit; Gajović, Srećko; Imširović, Alen; Bakula, Marina; Mahiiovych, Solomiia; Gaspar, Robert; Vari, Sandor G; Heffer, Marija
Frontiers in endocrinology (Lausanne), 10/2023, Letnik: 14Journal Article
The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old. Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes. Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.
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