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Kramer, Mark S.; Cutler, Neal; Feighner, John; Shrivastava, Ram; Carman, John; Sramek, John J.; Reines, Scott A.; Liu, Guanghan; Snavely, Duane; Wyatt-Knowles, Edwina; Hale, Jeffrey J.; Mills, Sander G.; MacCoss, Malcolm; Swain, Christopher J.; Harrison, Timothy; Hill, Raymond G.; Hefti, Franz; Scolnick, Edward M.; Cascieri, Margaret A.; Chicchi, Gary G.; Sadowski, Sharon; Williams, Angela R.; Hewson, Louise; Smith, David; Carlson, Emma J.; Hargreaves, Richard J.; Nadia M. J. Rupniak
Science (American Association for the Advancement of Science), 09/1998, Letnik: 281, Številka: 5383Journal Article
The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties. Like clinically used antidepressant and anxiolytic drugs, substance P antagonists suppressed isolation-induced vocalizations in guinea pigs. In a placebo-controlled trial in patients with moderate to severe major depression, robust antidepressant effects of the substance P antagonist MK-869 were consistently observed. In preclinical studies, substance P antagonists did not interact with monoamine systems in the manner seen with established antidepressant drugs. These findings suggest that substance P may play an important role in psychiatric disorders.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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