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Racle, Julien; Michaux, Justine; Rockinger, Georg Alexander; Arnaud, Marion; Bobisse, Sara; Chong, Chloe; Guillaume, Philippe; Coukos, George; Harari, Alexandre; Jandus, Camilla; Bassani-Sternberg, Michal; Gfeller, David
Nature biotechnology, 11/2019, Letnik: 37, Številka: 11Journal Article
Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II) have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased mass spectrometry with a motif deconvolution algorithm to profile and analyze a total of 99,265 unique peptides eluted from HLA-II molecules. We then trained an epitope prediction algorithm with these data and improved prediction of pathogen and tumor-associated class II neoepitopes.
