We researched a hypothetical model of factors influencing successful change implementation in fourteen Slovene hospitals for the following independent variables: organizational culture, teamwork, leadership models, informational support for work processes, and hospital organization. The research included dependent variable: current situation of successful change implementation approaches. The results are based on a 9% sample of employees (759 respondents) from three personnel categories (medicine, nursing, non-health care professionals). The results have revealed that teamwork is the independent variable which explained successful change implementation in hospitals most highly. The research has shown that a reform of the management sector in Slovene hospitals is needed in terms of gaining new knowledge and participating in management training programs which also include change implementation.