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  • Immunotherapy of Central Ne...
    Heimberger, Amy B.; Reardon, David A.; Bigner, Darell D.; Sampson, John H.

    Brain Tumors
    Book Chapter

    The overall objective of this chapter is to evaluate significant progress and research advances within the field of immunotherapy and to delineate the challenges associated with the utilization of immunotherapies that are unique to central nervous system (CNS) tumors. Immunotherapy of CNS tumors is complicated by multiple factors, such as, tumor heterogeneity, immunosuppression, and immunologic privilege. The study of immunotherapies requires a thorough knowledge of immunological response within the CNS and its potential consequences, including the induction of autoimmune disorders, is mandatory.