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Costachescu, Radmila Elena; Pienar, Corina; Pop, Liviu
Archives of disease in childhood, 06/2019, Letnik: 104, Številka: Suppl 3Journal Article
Crohn’s disease (CD) is an inflammatory bowel disease (IBD) of multifactorial etiology that affects all segments of the gastrointestinal tract and is associated with multiple extra-intestinal manifestations. Spondyloarthropathies are the most common extra-digestive manifestation of IBD’s. Spondyloarthropathies primarily involve the axial skeleton, but mai also be associated with peripheral symptoms such as synovitis, dactylitis or enthesitis.ObjectivesCase presentation of a teenager, aged 14, diagnosed with CD A1 L3L4B1p-score PCDAI 45, (November 2018) that presented with joint manifestations as a form of onset.Case presentationThe patient exhibits joint pain at the level of large joints of self-limiting character, as well as pain at the level of the costochondral joints associated with fever spikes. In recent history, over a period of two months, the patient presented up to 10 stools/day, without pathological features, with consecutive weight loss. An infectious etiology was suspected and empiric antibiotic treatment was instituted, with the evolution being unfavorable.She is admitted to the clinic for further investigation and treatment. Biologically she presented: marked inflammatory syndrome, reactive thrombocytosis, hypochromic microcytic anemia, positive calprotectin. The suspicion of an IBD, is raised, multiple biopsies from the upper digestive tract being performed. The macro and microscopic appearance suggested Crohn’s disease in the stage of active lesions. Induction therapy with exclusive enteral nutrition (EEN) is established, as well as azathioprine, to maintain remission. Evolution is favorable with the remission of joint symptoms in the first 2 weeks of EEN.ConclusionIn some cases, patients with Crohn’s disease, due to chronic inflammatory syndrome, may develop symptoms similar to those encountered in spondyloarthropathies.
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