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  • Dose Rate Effect of Pulsed ...
    Acharya, Santhosh (Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, India); Sanjeev, Ganesh (Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, India); Bhat, Nagesh (Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, India); Narayana, Yerol (Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, India)

    Arhiv za higijenu rada i toksikologiju, 03/2010, Letnik: 61, Številka: 1
    Journal Article

    The micronucleus assay in human peripheral blood lymphocytes is a sensitive indicator of radiation damage and could serve as a biological dosimeter in evaluating suspected overexposure to ionising radiation. Micronucleus (MN) frequency as a measure of chromosomal damage has also extensively been employed to quantify the effects of radiation dose rate on biological systems. Here we studied the effects of 8 MeV pulsed electron beam emitted by Microtron electron accelerator on MN induction at dose rates between 35 Gy min -1 and 352.5 Gy min -1 . These dose rates were achieved by varying the pulse repetition rate (PRR). Fricke dosimeter was employed to measure the absorbed dose at different PRR and to ensure uniform dose distribution of the electron beam. To study the dose rate effect, blood samples were irradiated to an absorbed dose of (4.7±0.2) Gy at different rates and cytogenetic damage was quantified using the micronucleus assay. The obtained MN frequency showed no dose rate dependence within the studied dose rate range. Our earlier dose effect study using 8 MeV electrons revealed that the response of MN was linear-quadratic. Therefore, in the event of an accident, dose estimation can be made using linear-quadratic dose response parameters, without adding dose rate as a correction factor. Mikronukleus-test pokazao se osjetljivim pokazateljem oštećenja u limfocitima periferne ljudske krvi te se primjenjuje kao biološki dozimetar posumnja li se na prekomjerno izlaganje ionizirajućem zra _enju. Mikronukleusi kao mjera oštećenja kromosoma _esto se rabe za procjenu u _inaka zra _enja u biološkim sustavima. Ovdje je istraženo djelovanje pulsnoga elektronskoga snopa od 8 MeV, dobivenog s pomoću elektronskoga akceleratora marke Microtron, na nastanak mikronukleusa u rasponu brzina doza od 35 Gy min -1 do 352.5 Gy min -1 . Brzine doza mijenjale su se mijenjajući brzinu ponavljanja pulsa (tzv. pulse repetition rate, krat. PRR). Za mjerenje apsorbirane doze pri razli _itim PRR-ovima rabio se Frickeov dozimetar. Dozimetrijska su mjerenja također poslužila za ujedna _avanje doze elektronskoga snopa. Za istraživanje utjecaja brzine doze, uzorci krvi ozra _eni tako da apsorbiraju dozu od (4.7±0.2) Gy pri razli _itim brzinama doze, a zatim se s pomoću mikronukleus-testa utvrdilo citogenetsko oštećenje. Pokus s pulsnim snopovima energije 8 MeV upućuje na neovisnost broja mikronukleusa o brzinama doze u rasponu ispitanome u ovom istraživanju. Naše ranije istraživanje utjecaja doze pulsnoga elektronskoga zra _enja energije 8 MeV upozorilo je na linearni do kvadratni odgovor izmjerenih parametara. Stoga se akcidentalna doza može procijeniti s pomoću linearnih do kvadratnih parametara odgovora na dozu, bez potrebe za korekcijom s pomoću brzine doze.