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Mout, Rubul; Ray, Moumita; Lee, Yi-Wei; Scaletti, Federica; Rotello, Vincent M
Bioconjugate chemistry, 04/2017, Letnik: 28, Številka: 4Journal Article
The successful use of clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-based gene editing for therapeutics requires efficient in vivo delivery of the CRISPR components. There are, however, major challenges on the delivery front. In this Topical Review, we will highlight recent developments in CRISPR delivery, and we will present hurdles that still need to be overcome to achieve effective in vivo editing.
