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Ewens, Kathryn G., Ph.D; Jones, Michelle R., B.Sc; Ankener, Wendy, B.S; Stewart, Douglas R., M.D; Urbanek, Margrit, Ph.D; Dunaif, Andrea, M.D; Legro, Richard S., M.D; Chua, Angela, B.S; Azziz, Ricardo, M.D., M.B.A., M.P.H; Spielman, Richard S., Ph.D; Goodarzi, Mark O., M.D., Ph.D; Strauss, Jerome F., M.D., Ph.D
Fertility and sterility, 06/2011, Letnik: 95, Številka: 8Journal Article
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
