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Toratani, Akihisa; Sawada, Shohei; Kono, Yoshihito; Higaki, Tadashi; Imamura, Hitoshi; Tada, Yusuke; Yamasaki, Seiki; Sato, Toshiyuki; Komatsu, Sumio; Akamatsu, Naoaki; Tamagaki, Toshiyuki; Nakagawa, Katsumi; Tsuji, Hajime; Nakagawa, Masao
Journal of cardiovascular pharmacology, 1999-June, Letnik: 33, Številka: 6Journal Article
This study was conducted to evaluate the effects of interleukin-1α (IL-1α) on prostacyclin (PGI2) production in cultured human vascular endothelial cells in association with intracellular Ca, inositol 1,4,5-trisphosphate (IP3), and with prostaglandin H synthase (PGHS) and phospholipase A2 (PLA2) gene expression by using the competitive polymerase chain reaction (PCR) method. IL-1α did not increase PGI2 production for 15 min, but induced an increase of about three-fold relative to that in controls at 60 and 180 min. IL-1α had no effect on intracellular Ca levels throughout the experimental period. In this study, consistent with previous reports, PGHS-1 messenger RNA (mRNA) was constitutively expressed, whereas PLA2 mRNA was not. After stimulation with IL-1α, PLA2 mRNA level showed an eightfold increase within 15 min, and PGHS-2 mRNA level increased by 76-fold within 180 min. PGHS-1 mRNA level was increased 1.6-fold at 180 min. These results suggest the existence of regulatory mechanisms of IL-1α-induced PGI2 production, which involve PGHS and PLA2 gene transcription.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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