The existing correlations between pile and cone penetration test (CPT) results often lack versatility for silty geomaterials, as they were primarily developed for clays or sands. To establish meaningful correlations, it is essential to understand the geology of the environment under examination. The CPT and its derived parameters, including the Soil Behavior Type (SBT) index, have proven to provide reliable soil information, particularly in the field of pile foundation engineering. This paper presents the findings and interpretations from several pile load tests conducted alongside field cone penetration tests on a Holocene saline interlayered silty formation, a distinct condition encountered in practice. Various CPT-based pile design methods were employed to evaluate pile capacity based on CPT results. As observed, predictions for pile shaft resistance in this geological formation remained consistent across all methods, while notable variations emerged in estimating pile end bearing. This was inferred to be a result of limited research on pile end bearing capacity in the literature, leading to proposals of broad ranges for pile influence zone and toe coefficient values, as well as various CPT tip resistance averaging techniques across different methods. Consequently, to improve accuracy, modifications based on site-specific test data may be necessary. Drawing from the assessments, effective modifications involved considering the SBT index near the pile tip. Subsequently, the current study introduces a new region-specific adjustment to the widely recognized Enhanced Unicone method based on the SBT index, resulting in a more accurate estimate of pile end bearing in such interlayered silty contexts, with less scatter compared to other available approaches.