Wheat is one of the most important cereal and it is considered primarily as a source of energy (carbohydrate), in human diet. In Serbia, the most farms producing crops, where wheat is one of the most important crop. The paper investigates differences in efficiency of wheat production among Serbian farms with objective to identify the most efficient farms and possibilities for further improvement. Data for 2015/2016 production year are gathered through questionnaire during farms visit. In the paper non-parametric models of Data Envelopment Analysis (DEA) was used to identify differences in effciency of wheat production among farms. The results reveal importance of farm size, size of plots and investments in the new machinery.