Provider: - Institution: - Data provided by Europeana Collections- Neonatal infections caused by bacteria and viruses, primarily by equine herpes virus 1, together with neonatal septicaemia, present the majore causes of newborne foal loss. The key problem is most often insufficient transfer of colostral immunity. Assessment of immunity status in newborne foals has a great importance in diagnostics, prediction and prevention of neonatal infection. By timely substitution of immunoglobulin in cases of insufficient transfer of colostral antibodies, complications leading to death of newborn foals can be prevented. Testing of passive transfer of colostral immunoglobulin, content of certain serum protein fraction, IgG and titres of specific antibodies against equne herpes virus 1 in newborn foal was done in two Lipizzaner and Trotter farms. The testing included 12 Lipizzaner mares, not vaccinated against equine herpes virus 1, including their 12 foals, and 12 American and Serbian Trotter mares which were three times vaccinated during pregnancy against equine herpes virus 1, including their 12 foals too. Six foals from each group received their first colostrums with zeolite based mineral adsorbent, while the other 6 foals received colostrums without zeolite. Analysis of the obtained results proved correlation between gamma globulin concentration in mare serum and the content of immunoglobulin in their colostrum, without statistically significant differences between the two group of mares, but with statistically significant differences in titres of specific antibodies against equine herpes virus 1.The results obtained also pointed to absence of specific antibodies against equine herpes virus 1 and presence of minimum quantities of immunoglobulin in blood serum of the newborn foals before taking colostrum, as well as to a significant increase of total protein concentration, primarily gamma globulin and immunoglobulin G in blood serum of the newborn foals after taking colostrum. The increase of gamma globulin and immunoglobulin G was at the highest during the first 24 hours. Also, the correlation between the content of gamma globulin and immunoglobulin G in serum of the newborn foals and the content of gamma globulin and immunoglobulin G in serum and colostrum of their mothers was confirmed. In foals delivered by vaccinated mares, after taking colostrum, there was a significant increase of titres of specific antibodies against herpes virus 1. The content of immunoglobulin in blood serum of the foals fed by colostrum with zeolite, was a little bigger, but without statistical significance.- Neonatalne infekcije bakterijama i virusima, pre svega infekcija konjskim herpesvirusom 1 i neonatalna septikemija, predstavljaju glavni uzrok gubitaka novorođene ždrebadi. Ključni problem je najčešće nedovoljan transfer kolostralnog imuniteta. Procena imunog statusa kod novorođene ždrebadi ima veliki značaj u dijagnostici, predviđanju i preveniranju neonatalnih infekcija. Pravovremenom supstitucijom imunoglobulina u slučaju nedovoljnog transfera kolostralnih antitela, naime, mogu se sprečiti komplikacije koje su veoma često odgovorne za uginuće novorođene ždrebadi. Ispitivanje pasivnog transfera kolostralnih imunoglobulina, sadržaja pojedinih frakcija serumskih proteina, IgG i titra specifičnih antitela protiv konjskog herpesvirusa 1 kod novorođene ždrebadi izvedeno je na dve ergele lipicanera i kasača. Ispitivanjem je obuhvaćeno 12 kobila lipicanske rase, koje nisu vakcinisane protiv konjskog herpesvirusa 1, uključujući i njihovih 12 ždrebadi, zatim na 12 kobila rase američki i srpski kasač, koje su tokom graviditeta trokratno vakcinisane protiv herpesvirusa 1, uključujući, takođe, i njihovih 12 ždrebadi. Po 6 ždrebadi iz svake grupe je, pri tome, neposredno posle rođenja u prvom napoju dobilo kolostrum sa dodatkom mineralnog adsorbenta na bazi zeolita, dok je drugih 6 dobilo kolostrum bez zeolita. Analizom dobijenih rezultata dokazana je korelacija između koncentracije gama globulina u krvnom serumu kobila i sadržaja imunoglobulina u njihovom kolostrumu, bez statistički značajnih razlika između dve grupe kobila, uz postojanje statistički značajnih razlika između dve grupe kobila u titru specifičnih antitela protiv konjskog herpesvirusa 1. Dobijeni rezultati takođe ukazuju na odsustvo specifičnih antitela protiv konjskog herpesvirusa 1 i prisustvo minimalnih količina imunoglobulina u krvnom serumu novorođene ždrebadi pre uzimanja kolostruma, zatim na značajno povećanje koncentracije ukupnih proteina, pre svega gama globulina i imunoglobulina G u krvnom serumu novorođene ždrebadi nakon uzimanja kolostruma. Povećanje koncentracije gama globulina i imunoglobulina G najveće je u prvih 24 časa. Pri tome je potvrđena korelacija između sadržaja gama globulina i imunoglobulina G u serumu novorođene ždrebadi sa sadržajem gama globulina i imunoglobulina G u serumu i kolostrumu njihovih majki. Kod ždrebadi poreklom od vakcinisanih kobila nakon uzimanja kolostruma dolazi do značajnog povećanje titra specifičnih antitela protiv herpesvirusa 1. Sadržaj imunoglobulina u krvnom serumu je pri tome nešto veći u grupi ždrebadi koja su u napoju kolostruma dobijala i zeolit, međutim, ova razlika nije statistički značajna.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana