The purpose of this study was to investigate the relationship between emotional deprivation, social companionship and loneliness in organization with wellbeing in work while examining the effect of job control moderator. This study was applied in a descriptive and surveyed manner. The statistical population of this study was 212 employees of public organizations of Semnan who were selected through Accessible sampling. Structural equations’ modeling was used to analyze research data with Smart-PLS software. To assess the validity of convergent validity, the software was used and the cronbach alpha was used to fit the reliability, and its coefficient for all research structures was more than 0.7. The results show that emotional deprivation has a positive and significant effect on loneliness in organization, but social Companionship has a negative and significant effect on the level of employee loneliness. The results of the research confirmed the positive and significant effect of loneliness and wellbeing in work. Also, loneliness in the organization mediates the relationship between emotional deprivation and wellbeing, but does not mediate the relationship between social companionship and wellbeing. Nevertheless, job control modifies the relationship between loneliness in organization and sense of wellbeing.