ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Irisin attenuates muscle impairment during bed rest through muscle-adipose tissue crosstalk [Elektronski vir]D'Amuri, Andrea ...Simple Summary: Irisin is a known myokine secreted mainly by the muscle that is produced after physical activity. It induces browning in the adipose tissue with a consequent increase in mitochondrial ... oxidation of lipids and reduction of insulin resistance; thus, it has been hypothesized that irisin was the molecule mediating most of the beneficial effects related to exercise on adipose tissue and consequently on the whole organism. In our study we observed that extreme physical inactivity induces the loss of muscle mass and function, and an increase in the body adipose tissue as expected. However, of note, circulating irisin levels were increased secondary to enhanced irisin synthesis mainly from adipose tissue rather than muscle. In addition, subjects who produced more irisin had reduced muscle impairment. Therefore, our hypothesis is that there is negative feedback within the muscle-adipose tissue crosstalk, specifically not only does the muscle influence the adipose tissue through irisin during exercise, but also the adipose tissue protects the muscle during inactivity.Source: Biology [Elektronski vir]. - ISSN 2079-7737 (Vol. 11, iss. 7, 2022, str. 1-14)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 114611459
Digital content: dCOBISS
Source: Personal bibliographies
and: SICRIS
