-
Impact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism [Elektronski vir]Oranger, Angela ...The bed rest (BR) is a ground-based model to simulate microgravity mimicking skeletal-muscle alterations as in spaceflight. Molecular coupling between bone and muscle might be involved in ... physiological and pathological conditions. Thus, the new myokine irisin and bone-muscle turnover markers have been studied during and after 10 days of BR. Ten young male individuals were subjected to 10 days of horizontal BR. Serum concentrations of irisin, myostatin, sclerostin, and haptoglobin were assessed, and muscle tissue gene expression on vastus lateralis biopsies was determined. During 10-days BR, we observed no significant fluctuation levels of irisin, myostatin, and sclerostin. Two days after BR (R+2), irisin serum levels significantly decreased while myostatin, sclerostin, and haptoglobin were significantly increased compared with BR0. Gene expression of myokines, inflammatory molecules, transcription factors, and markers of muscle atrophy and senescence on muscle biopsies were not altered, suggesting that muscle metabolism of young, healthy subjects is able to adapt to the hypomobility condition during 10-day BR. However, when subjects were divided according to irisin serum levels at BR9, muscle ring finger-1 mRNA expression was significantly lower in subjects with higher irisin serum levels, suggesting that this myokine may prevent the triggering of muscle atrophy. Moreover, the negative correlation between p21 mRNA and irisin at BR9 indicated a possible inhibitory effect of the myokine on the senescence marker. In conclusion, irisin could be a prognostic marker of hypomobility-induced muscle atrophy, and its serum levels could protect against muscle deterioration by preventing and/or delaying the expression of atrophy and senescence cellular markers.Source: The FASEB journal [Elektronski vir]. - ISSN 1530-6860 (Vol. 37, iss. 1, Jan. 2023, str. 1-13)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 133716995
Author
Oranger, Angela |
Storlino, Giuseppina |
Dicarlo, Manuela |
Zerlotin, Roberta |
Pignataro, Patrizia |
Sanesi, Lorenzo |
Narici, Marco Vicenzo |
Pišot, Rado |
Šimunič, Boštjan |
Colaianni, Graziana
Topics
gibalna neaktivnost |
bed rest |
celična senesenca |
haptoglobin |
irisin |
mišična atrofija |
miostatin |
sklerostin |
physical inactivity |
cell senescence |
muscle atrophy |
myostatin |
sclerostin
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Oranger, Angela | |
Storlino, Giuseppina | |
Dicarlo, Manuela | |
Zerlotin, Roberta | |
Pignataro, Patrizia | |
Sanesi, Lorenzo | |
Narici, Marco Vicenzo | 38863 |
Pišot, Rado | 11612 |
Šimunič, Boštjan | 21102 |
Colaianni, Graziana |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.