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Engineered combinatorial cell device for wound healing and bone regeneration [Elektronski vir]Kadunc, Lucija ...Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted ... growth factors underlies stem cell–mediated regeneration. To avoid the potential dangers and laborintensive individual approach of stem cell therapy while maintaining their regeneration-promoting effects based on multiple secreted growth factors, we engineered a “mix-and-match” combinatorial platform based on a library of cell lines producing growth factors. Treatment with a combination of growth factors secreted by engineered mammalian cells was more efficient than with individual growth factors or even stem cell–conditioned medium in a gap closure assay. Furthermore, we implemented in a mouse model a device for allogenic cell therapy for an in situ production of growth factors, where it improved cutaneous wound healing. Augmented bone regeneration was achieved on calvarial bone defects in rats treated with a cell device secreting IGF, FGF, PDGF, TGF-β, and VEGF. In both in vivo models, the systemic concentration of secreted factors was negligible, demonstrating the local effect of the regeneration device. Finally, we introduced a genetic switch that enables temporal control over combinations of trophic factors released at different stages of regeneration mimicking the maturation of natural wound healing to improve therapy and prevent scar formation.Source: Frontiers in bioengineering and biotechnology [Elektronski vir]. - ISSN 2296-4185 (Vol. 11, 2023, str. 1-16)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 152044035
Author | Kadunc, Lucija ... |
Title | Engineered combinatorial cell device for wound healing and bone regeneration [Elektronski vir] |
Publication date | 2023-01-01 |
COBISS.SI-ID | 152044035 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Sintezna biologija in imunologija | P4-0176-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Načrtovanje hitro odzivne signalne in logične poti na osnovi ortogonalnih proteaz | J1-9173-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Optimizacija sinteznobioloških genskih vezij in reprogramiranja celic s pomočjo mikrofluidike | N4-0080-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Sintezno biološki pristop k celjenju ran in nevroregeneraciji | J3-6791-2014 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Vloga celične smrti v različnih aktivacijskih poteh inflamasoma NLRP3 in njena uporaba za inovativno imunoterapijo raka | J3-1746-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Proteoliza in njena regulacija pri zdravju in boleznih | P1-0140-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Parodontalna medicina | P3-0293-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Plastičnost živčevja v fizioloških in patofizioloških razmerah | P3-0171-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://www.frontiersin.org/articles/10.3389/fbioe.2023.1168330/full |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=155119 |
https://dirros.openscience.si/IzpisGradiva.php?id=16610 |
Costs of publication
Cost type | Total cost | Payments |
---|---|---|
APC – Article Processing Charge | 2734.85 € |
2734.85 € : Kemijski inštitut |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kadunc, Lucija | 36853 |
Lainšček, Duško | 34069 |
Gašperšič, Rok, 1972- | 19210 |
Sušjan, Petra | 37644 |
Kovačič, Uroš, 1975- | 22360 |
Butinar, Miha | 33315 |
Turk, Boris, 1964- | 07561 |
Jerala, Roman | 06628 |
Hafner Bratkovič, Iva, 1978- | 23563 |
Source: Personal bibliographies
and: SICRIS
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