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Večfaktorska analiza koncentracij tumorskih označevalcev CA125, TPA in RCAS1 vserumu pri vrednotenju patologije jajčnikov = Multifactor analysis of CA125, TPA and RCAS1 tumor markers serum concentrations in ovarian cancer screening : magistrska nalogaSnoj, Nada, 1966-The use of serum tumor markers for the early detection of ovarian cancer has been limited because of their low sensitivity, specificity and low positive predictive value. We analyzed three tumor ... markers CA125, TPA and RCAS1 with a high likelihood of improving the diagnostic accuracy for early detection. Samples were obtained from 130 patients with benign, 14 patients with borderline, 64 patients with malignant ovarian neoplasm and from 82 healthy women. Reference intervals were determined for all three tumor markers. There was statistically significant difference in CA125 and TPA concentrations between premenopausal and postmenopausal healthy women and TPA concentrations increase statistically significant with the age of the healthy women. There was statistically significant correlation between measured tumor markers in whole investigated population of women. CA125, TPA and RCAS1 concentrations were significantly different between healthy women and patients with benign, borderline and malignant ovarian neoplasm (MANOVA p<0,001) and also between premenopausal and postmenopausal women (MANOVA p=0,026). There were no statistically significant differences in tumor markers concentrations between premenopausal and postmenopausal patients within the groups of patients considering histopathologic diagnosis (MANOVA p=0,763). We found that complementarity exists between the measured tumor markers. Among patients withclinically evident malignant tumors and negative CA125, 40% had elevated TPA and 60% had elevated RCAS 1 levels. (Abstract truncated at 2000 characters)Type of material - master's thesisPublication and manufacture - Ljubljana : [N.Snoj], 2005Language - slovenianCOBISS.SI-ID - 20676569
Author
Snoj, Nada, 1966-
Other authors
Osredkar, Joško, 1955-
Topics
Tumor Markers, Biological |
Ovarian Neoplasms |
Diagnosis |
Ca-125 Antigen |
Tissue Polypeptide Antigen |
Roc Curve |
Multivariate Analysis |
Sensitivity And Specificity |
Ca-125 antigen |
Jajčnik, novotvorbe |
ROK krivulja |
Tkivni, polipeptidni antigen |
Tumorski označevalci biološki |
Multivariatna analiza |
Občutljivost in specifičnost
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Database name | Field | Year |
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Snoj, Nada, 1966- | 15984 |
Osredkar, Joško, 1955- | 10691 |
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