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Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular riskJuhan-Vague, Irene ...Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to impaired ... fibrinolysis caused by increased plasma PAI-1 levels. Although the etiology of IRS is far from being explained,the clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link. Proinflammatory cytokines might regulate PAI-1 expression in IRS; however, more studies are needed to confirm this complex mechanism in humans. Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes.Source: Journal of thrombosis and haemostasis. - ISSN 1538-7933 (Letn. 1, št. 7, 2003, str. 1575-1579)Type of material - article, component partPublish date - 2003Language - english, slovakCOBISS.SI-ID - 23096537
Author
Juhan-Vague, Irene |
Alessi, Marie-Christine |
Mavri, Alenka |
Morange, Pierre-François.
Topics
Insulin Resistance |
Animals |
Heart Diseases |
Metabolism |
Obesity |
Metabolism |
Plasminogen Activator Inhibitor 1 |
Metabolism |
Physiology |
Risk |
Insulinska rezistenca |
Debelost |
Plazminogen aktivator, inhibitor 1 |
Srce, bolezni |
Tveganje |
Živali
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Database name | Field | Year |
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Juhan-Vague, Irene | ![]() |
Alessi, Marie-Christine | ![]() |
Mavri, Alenka | 14642 |
Morange, Pierre-François. | ![]() |
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