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  • Munc18-1, exocytotic fusion pore regulation and local membrane anisotropy [Elektronski vir]
    Jorgačevski, Jernej ; Zorec, Robert, 1958-
    The release of hormones and neurotransmitters from vesicles can be modified bythe regulation of the fusion pore, an aqueous channel that forms upon the fusion of the vesicle membrane with the plasma ... membrane. However, the mechanisms are unclear. Munc18-1 protein interacts with Syntaxin1 (Synt 1), a member of the SNARE proteins, which plays an important role in exocytosis. It has been shown that Munc18-1 has multiple roles, both in pre- and post-fusion stages of exocytosis. It regulates the traffic of Synt1 to the plasma membrane. By inhibiting the tethering of the vesicle SNARE protein Synaptobrevin 2 (Syb2) solely to Synt1 at the plasma membrane, but favoring the vesicular tethering to the preformed binary cis SNARE complex of Synt1A-SNAP25B, Munc18-1 is tuning vesicle docking and the membrane merger process. Additionally, Munc18-1 affects exocytosis at the post-fusion stage byregulating the fusion pore properties (i.e. dwell-time and fusion pore diameter). Among many possible mechanisms that may regulate the fusion pore, but have never been considered previously, is the influence of Munc18-1 on themembrane anisotropy, which determines the local spontaneous membrane curvature and the architecture of the fusion pore. We here propose that Munc18-1 affects the fusion pore by modulating the dynamic local (re)arrangement of anisotropic membrane components within the highly curved fusion pore nanostructure, to which proteins, lipids or their complexes can participate.
    Source: Communicative & integrative biology [Elektronski vir]. - ISSN 1942-0889 (Vol. 5, issue 1, 2012, str. 74-77)
    Type of material - e-article
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 29350617

    Link(s):

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291320/pdf/cib-5-74.pdf

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