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Karcinom Merklovih celic - novosti v sistemskem zdravljenju = Merkel cell carcinoma - innovations in systemic treatmentOcvirk, JanjaKarcinom Merklovih celic (KMC) je redek, agresiven nevroendokrini kožni rak s slabo prognozo, posebno, ko je v napredovalem stadiju. Incidenca na splošno narašča, čeprav podatki o incidenci kažejo na ... razlike med geografskimi področji. Med dejavnike tveganja štejemo starost, imunosupresijo in izpostavljenost ultravijoličnemu sevanju. Znana je povezava med MCC in okužbo s poliomavirusom, čeprav natančnega mehanizma, ki vodi v karcinogenezo, še ne razumemo v celoti. Pri lokalizirani bolezni je izbor zdravljenja kirurgija (ko je to mogoče), sledi mu dopolnilno obsevanje ali obsevanje v kombinaciji s kemoterapijo. Pri razsejani bolezni je bila doslej na voljo le kemoterapija, čeprav so dolgotrajni odgovori ob njej redki. Glede na to, da je onkogeneza tumorja povezana z integracijo poliomavirusa Merklovih celic in mutacijami, povzročenih z ultravijoličnim sevanjem, obstaja logična osnova za zdravljenje z imunoterapijo oz. protitelesi, ki ciljajo pot PD-L1/PD-1. Nedavno objavljene raziskave v prvem in drugem redu zdravljenja z inhibitorji imunskih stikal (anti-PD-1/PD-L1-protitelesi) kažejo obetajoče rezultate s sprejemljivim varnostnim profilom zdravljenja, zato tovrstno zdravljenje postaja standardno in je že priporočeno v mednarodnih smernicah za zdravljenje razsejanega raka Merklovih celic. Objavljeni podatki randomiziranih raziskav kažejo na obetajočo učinkovitost teh zdravil pri metastatski bolezni.Source: Onkologija : strokovni časopis za zdravnike. - ISSN 1408-1741 (Letn. 22, št. 2, dec. 2018, str. 20-25)Type of material - article, component partPublish date - 2018Language - slovenianCOBISS.SI-ID - 3137403
Author
Ocvirk, Janja
Topics
karcinom Merklovih celic |
nemelanomski kožni rak |
razsejana bolezen |
kemoterapija |
imunoterapija
source: Onkologija : strokovni časopis za zdravnike. - ISSN 1408-1741 (Letn. 22, št. 2, dec. 2018, str. 20-25)
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Ocvirk, Janja | 13541 |
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