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Large liver blood vessels and bile ducts are not damaged by electrochemotherapy with bleomycin in pigs [Elektronski vir]Žmuc, Jan ...The first clinical studies on the use of electrochemotherapy to treat liver tumours that were not amenable to surgery or thermal ablation techniques have recently been published. However, there is ... still a lack of data on the effects of electrochemotherapy on normal liver tissue. Therefore, we designed a translational animal model study to test whether electrochemotherapy with bleomycin causes clinically significant damage to normal liver tissue, with emphasis on large blood vessels and bile ducts. We performed electrochemotherapy with bleomycin or delivered electric pulses alone using a potentially risky treatment strategy in eight pigs. Two and seven days after treatment, livers were explanted, and histological analysis was performed. Blood samples were collected before treatment and again before euthanasia to evaluate blood biomarkers of liver function and systemic inflammatory response. We found no thrombosis or other clinically significant damage to large blood vessels and bile ducts in the liver. No clinical or laboratory findings suggested impaired liver function or systemic inflammatory response. Electrochemotherapy with bleomycin does not cause clinically significant damage to normal liver tissue. Our study provides further evidence that electrochemotherapy with bleomycin is safe for treatment of patients with tumours near large blood vessels in the liver.Source: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 9, no. 1, 2019, str. [1-11])Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 3174523
Author
Žmuc, Jan |
Gašljević, Gorana |
Serša, Gregor |
Edhemović, Ibrahim |
Boc, Nina, dr. med. |
Seliškar, Alenka |
Plavec, Tanja, veterinarka |
Brložnik, Maja |
Milevoj, Nina |
Brecelj, Erik |
Kos, Bor |
Izlakar, Jani |
Jarm, Tomaž |
Snoj, Marko, 1958- |
Štukelj, Marina |
Miklavčič, Damijan |
Čemažar, Maja
Topics
elektrokemoterapija |
bleomycin |
krvne žile |
jetra |
eksperimentalna onkologija |
electrochemotherapy |
bleomycin |
blood vessels |
liver |
experimental oncology
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Žmuc, Jan | 39826 |
Gašljević, Gorana | 36115 |
Serša, Gregor | 08800 |
Edhemović, Ibrahim | 17172 |
Boc, Nina, dr. med. | 39650 |
Seliškar, Alenka | 18593 |
Plavec, Tanja, veterinarka | 25588 |
Brložnik, Maja | 57701 |
Milevoj, Nina | 39087 |
Brecelj, Erik | 18298 |
Kos, Bor | 30687 |
Izlakar, Jani | 51448 |
Jarm, Tomaž | 14772 |
Snoj, Marko, 1958- | 12250 |
Štukelj, Marina | 19156 |
Miklavčič, Damijan | 10268 |
Čemažar, Maja | 14575 |
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