ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Serum amyloid A is a marker for pulmonary involvement in systemic sclerosis [Elektronski vir]Lakota, Katja ...Inflammation in systemic sclerosis (SSc) is a prominent, but incompletely characterized fea- ture in early stages of the disease. The goal of these studies was to determine the circulat- ing levels, ... clinical correlates and biological effects of the acute phase protein serum amyloid A (SAA), a marker of inflammation, in patients with SSc. Circulating levels of SAA were determined by multiplex assays in serum from 129 SSc patients and 98 healthy con- trols. Correlations between SAA levels and clinical and laboratory features of disease were analyzed. The effects of SAA on human pulmonary fibroblasts were studied ex vivo. Elevat- ed levels of SAA were found in 25% of SSc patients, with the highest levels in those with early-stage disease and diffuse cutaneous involvement. Significant negative correlations of SAA were found with forced vital capacity and diffusion capacity for carbon monoxide. Pa- tients with elevated SAA had greater dyspnea and more frequent interstitial lung disease, and had worse scores on patient-reported outcome measures. Incubation with recombinant SAA induced dose-dependent stimulation of IL-6 and IL-8 in normal lung fibroblasts in cul- ture. Serum levels of the inflammatory marker SAA are elevated in patients with early dif- fuse cutaneous SSc, and correlate with pulmonary involvement. In lung fibroblasts, SAA acts as a direct stimulus for increased cytokine production. These findings suggest that sys- temic inflammation in SSc may be linked to lung involvement and SAA could serve as a po- tential biomarker for this complication.Source: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 10, iss. 1, Jan. 2015)Type of material - e-articlePublish date - 2015Language - englishCOBISS.SI-ID - 31899609
Author
Lakota, Katja |
Carns, Mary, dr. med. |
Podlusky, Sofia |
Mrak Poljšak, Katjuša |
Hinchcliff, Monique |
Lee, Jungwha |
Tomšič, Matija, 1959- |
Sodin-Šemrl, Snežna, 1962- |
Varga, John
Topics
systemic sclerosis |
amyloid |
human pulmonary fibroblasts |
sistemska skleroza |
amiloid |
človekovih pljučnih fibroblastov
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Lakota, Katja | 28845 |
Carns, Mary, dr. med. | |
Podlusky, Sofia | |
Mrak Poljšak, Katjuša | 34804 |
Hinchcliff, Monique | |
Lee, Jungwha | |
Tomšič, Matija, 1959- | 13601 |
Sodin-Šemrl, Snežna, 1962- | 26481 |
Varga, John |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: