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Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirinStupnišek, Mirjana ...Recently, in rat abdominal aorta terminoterminal-anastomosis the stable gastric pentadecapeptide BPC 157 prevents obstructive thrombus formation and rapidly destroys already formed obstructive ... thrombus. Also, BPC 157 wound healing may signify the clot as conductive matrix or "scaffold" to speed up wound healing process, and decrease bleeding. Here, in rats, BPC 157 (10 [micro]g/kg, 10 ng/kg) improved always reduced bleeding time and amount of bleeding after (tail) amputation only, heparin (250 mg/kg, 25 mg/kg, 10 mg/kg i.v.), warfarin (1.5 mg/kg i.g. once daily for 3 consecutive days), aspirin (0.1 g/kg i.g. (once daily/3 consecutive days) or 1.0 g/kg i.p. once), and amputation associated with those agents application. BPC 157 counteracting regimens (i.v., i.p., i.g. (immediately after any challenge)) correspondingly follow the route of bleeding-agents application. All heparin-, warfarin-, and aspirin-rats and normal-rats that received BPC 157 exhibited lesser fall in platelets count. BPC 157 attenuated over-increased APTT-, TT-values in 10 mg/kg heparin-rats, but did not influence heparin activity (anti-Xa test). Indicatively, unless counteracted in BPC 157 rats, excessive bleeding-acute thrombocytopenia (< 20% of initial values in heparin-rats) approaches substantial fall in platelets count known in type II HIT. Also, BPC 157 markedly prolongs the survival time (heparin-rats, 25 mg/kg, right foot amputation).Source: Thrombosis research. - ISSN 0049-3848 (Vol. 129, is 5, May 2012, str. 652-659)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 34206681
Author
Stupnišek, Mirjana |
Franjic, Sandra |
Drmić, Domagoj |
Hrelec Patrlj, Masa |
Kolenc, Danijela |
Radic, Bozo |
Bojic, Davor |
Včev, Aleksandar |
Seiwerth, Sven |
Sikirić, Predrag
Topics
BPC 157 |
bleeding |
direct oral anticoagulants |
heparin |
BPC 157 |
krvavitev |
heparin
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Stupnišek, Mirjana | ![]() |
Franjic, Sandra | ![]() |
Drmić, Domagoj | ![]() |
Hrelec Patrlj, Masa | ![]() |
Kolenc, Danijela | 52857 |
Radic, Bozo | ![]() |
Bojic, Davor | ![]() |
Včev, Aleksandar | ![]() |
Seiwerth, Sven | ![]() |
Sikirić, Predrag | ![]() |
Source: Personal bibliographies
and: SICRIS
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