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Sistematični pregled izsledkov raziskav o razgradnji polisorbatov 20 in 80 v tekočih farmacevtskih oblikah = Systematic review of research results on degradation of polysorbates 20 and 80 in liquid pharmaceutical forms : magistrski študijski program Laboratorijska biomedicinaTerlep, NikaOzadje: Polisorbati se v farmacevtski industriji uporabljajo za preprečevanje fizičnih poškodb proteinov med različnimi industrijskimi postopki, skladiščenjem in dostavo farmacevtskega izdelka. Pod ... določenimi pogoji so nagnjeni k razgradnji, kar lahko negativno vpliva na stabilnost, kakovost in varnost izdelka. Namen: Pregledati literaturo in izdelati sistematični pregled izsledkov raziskav oksidativne razgradnje najbolj pogosto uporabljenih polisorbatov (polisorbat 20 in polisorbat 80). Določiti dejavnike oziroma faktorje, ki povzročajo oksidacijo v polisorbatih in razpadne produkte, ki nastanejo pri oksidaciji polisorbatov v tekočih farmacevtskih oblikah ter uporabljene analizne instrumentalne metode za detekcijo in kvantifikacijo razpadnih produktov. Metode: Z uporabo vnaprej določenega iskalnega profila smo v podatkovni bazi PubMed in Web of Science poiskali raziskave, objavljene do konca februarja 2020. Vključili smo raziskave, ki so vrednotile oksidativno razgradnjo polisorbatov 20 in 80 v tekočih farmacevtskih oblikah. Rezultati: V sistematičnem pregledu smo obravnavali 17 raziskav, ki so ustrezale vključitvenim in izključitvenim kriterijem. V objavljeni literaturi smo odkrili kar nekaj povzročiteljev oksidacije v polisorbatih in njihovih razpadnih produktov ter raznolikih analiznih instrumentalnih metod za detekcijo in kvantifikacijo razpadnih produktov.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [N. Terlep], 2020Language - slovenianCOBISS.SI-ID - 42205955
Author
Terlep, Nika
Other authors
Mravljak, Janez, 1978-
Topics
Farmacevtske oblike |
Farmacevtska industrija |
polisorbat 20 |
polisorbat 80 |
stabilnost |
oksidativna razgradnja |
razpadni produkti |
biofarmacevtska formulacija |
proteinska formulacija |
tekoča farmacevtska oblika
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Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Year | Impact factor | Edition | Category | Classification | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Terlep, Nika | ![]() |
Mravljak, Janez, 1978- | 23419 |
Source: Personal bibliographies
and: SICRIS
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