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  • Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus
    Vujasinović, Miroslav ...
    Introduction: Exocrine pancreatic insufficiency (EPI) can occur in patients with diabetes mellitus (DM). Incidence of EPI and its clinical significance remain poorly defined. The aim of our study was ... to determine whether exocrine pancreatic function is impaired in patients with DM. Patients and methods: One hundred and fifty consecutive patients, mean age 59.0 (+/- 12.0 years), with DM lasting at least 5 years were included in the study. We included 50 patients with type 1 DM (DM1), 50 insulin-treated patients DM type 2 (DM2-insulin) and 50 non-insulin treated patients with DM type 2 (DM2 no-insulin). Diagnosis of DM was established from health records, lasting 15.0 +/- 9.9 years on average. EPI was diagnosed with a fecal elastase-1 concentration (FE1) of less than 200 micro g/g (ELISA). Results: FE1 was reduced in 8 (5.4%) patients: mildly reduced (100-200 micro g/g) in 4 patients (2.7%) and markedly reduced (<100 micro g/g) in 4 patients (2.7%). Frequency of EPI was 3 in DM1, 5 in DM2(insulin) and none in DM2 (no-insulin) groups. Conclusions: EPI in DM occurred less frequently than in previous studies, probably due to our strict exclusion criteria (age, alcohol intake).
    Source: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. - ISSN 1424-3903 (Vol. 13, no. 4, 2013, str. 343-346)
    Type of material - article, component part ; adult, serious
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 4781631

    Link(s):

    http://www.sciencedirect.com/science/article/pii/S142439031300450X
    DOI

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