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Influence of linker attachment points on the stability and neosubstrate degradation of cereblon ligandsBricelj, Aleša ...Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ... ligands highly affect their aqueous stability and neosubstrate degradation features. This work provides a blueprint for the assembly of future heterodimeric CRBN-based degraders with tailored properties.Source: ACS Medicinal Chemistry Letters. - ISSN 1948-5875 (Vol. 12, iss. 11, 2021, str. 1733-1738)Type of material - article, component part ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 81287683
Author
Bricelj, Aleša |
Ng, Yuen Lam Dora |
Ferber, D. |
Kuchta, Robert |
Müller, Sina |
Monschke, Marius |
Wagner, Karl G. |
Krönke, Jan |
Sosič, Izidor |
Gütschow, Michael |
Steinebach, Christian
Topics
Farmacevtska kemija |
PROTACs |
CRBN |
stability |
neosubstrates |
medicinal chemistry
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bricelj, Aleša | 53656 |
Ng, Yuen Lam Dora | |
Ferber, D. | |
Kuchta, Robert | |
Müller, Sina | |
Monschke, Marius | |
Wagner, Karl G. | |
Krönke, Jan | |
Sosič, Izidor | 30816 |
Gütschow, Michael | |
Steinebach, Christian |
Source: Personal bibliographies
and: SICRIS
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