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Procesna analiza krušenja farmacevtske tablete : magistrsko delo magistrskega študijskega programa II. stopnje StrojništvoMurn, Blaž, strojnikDelo obravnava izzive krušenja in lomljenja farmacevtskih trdih oblik zdravil skozi celotno proizvodnjo. Tudi najmanjša deformacija vodi v izmet polizdelka, do katerega prihaja zaradi gravitacijskih ... spustov, ki so stalnica v vertikalni proizvodnji. Tablete morajo imeti zadostne mehanske lastnosti, da se preprečijo poškodbe med samim procesom proizvodnje. Hkrati pa morajo biti dovolj šibke, da jih končni uporabnik glede na navodila uporabe sam prelomi na enake dele oziroma se v telesu v določenem časovnem okvirju razgradijo in sprostijo aktivno farmacevtsko snov. V nalogi je predstavljen celoten proces proizvodnje, najpogostejši defekti kot tudi kontrola kakovosti farmacevtskih tablet. Za analizo krušljivosti smo uporabili preprost sistem za izvajanje gravitacijskih spustov iz različnih višin. Rezultate smo primerjali z numeričnimi simulacijami izvajanja farmacevtskega testa trdnosti kot tudi gravitacijskih spustov. Z vidika oblik polizdelkov smo deformacije med seboj primerjali. Ugotovili smo, da je izziv krušenja potrebno obravnavati celostno in ne zgolj z vidika oblike farmacevtskih tablet.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [B. Murn], 2022Language - slovenianCOBISS.SI-ID - 99937027
Author
Murn, Blaž, strojnik
Other authors
Golobič, Iztok |
Zupančič, Matevž, 1990-
Topics
magistrske naloge |
trda farmacevtska oblika zdravila |
proizvodnja tablet |
lomljivost |
krušljivost |
kontrola kakovosti |
master thesis |
hard pharmaceutical form of the drug |
tablet production |
friability |
breaking
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Mechanical Engineering, Ljubljana | Ljubljana | FSLJ |
reading room 1 cop.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Murn, Blaž, strojnik | |
Golobič, Iztok | 05566 |
Zupančič, Matevž, 1990- | 36685 |
Source: Personal bibliographies
and: SICRIS
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