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Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway [Elektronski vir]Janev, Aleksandar ...Bladder cancer is the 10th most commonly diagnosed cancer with the highest lifetime treatment costs. The human amniotic membrane (hAM) is the innermost foetal membrane that possesses a wide range of ... biological properties, including anti-inflammatory, antimicrobial and anticancer properties. Despite the growing number of studies, the mechanisms associated with the anticancer effects of human amniotic membrane (hAM) are poorly understood. Here, we reported that hAM preparations (homogenate and extract) inhibited the expression of the epithelial–mesenchymal transition markers N-cadherin and MMP-2 in bladder cancer urothelial cells in a dose-dependent manner, while increasing the secretion of TIMP-2. Moreover, hAM homogenate exerted its antimigratory effect by downregulating the expression of FAK and proteins involved in actin cytoskeleton reorganisation, such as cortactin and small RhoGTPases. In muscle-invasive cancer urothelial cells, hAM homogenate downregulated the PI3K/Akt/mTOR signalling pathway, the key cascade involved in promoting bladder cancer. By using normal, non-invasive papilloma and muscle-invasive cancer urothelial models, new perspectives on the anticancer effects of hAM have emerged. The results identify new sites for therapeutic intervention and are prompt encouragement for ongoing anticancer drug development studies.Source: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 13, iss. 1, 2023, str. 1-22)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 172516099
Author
Janev, Aleksandar |
Železnik Ramuta, Taja |
Dragin Jerman, Urška |
Obradović, Hristina |
Kamenšek, Urška |
Čemažar, Maja |
Erdani-Kreft, Mateja
Topics
Epithelial-mesenchymal transition |
muscles |
cell line, tumor |
cell movement |
cell proliferation |
humans |
mišice |
tumorska celična linija |
celično premikanje |
celična proliferacija |
ljudje
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Janev, Aleksandar | 51965 |
Železnik Ramuta, Taja | 39124 |
Dragin Jerman, Urška | 34354 |
Obradović, Hristina | |
Kamenšek, Urška | 28387 |
Čemažar, Maja | 14575 |
Erdani-Kreft, Mateja | 15873 |
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